PINK1 Deficiency Attenuates Astrocyte Proliferation Through Mitochondrial Dysfunction, Reduced AKT and Increased p38 MAPK Activation, and Downregulation of EGFR

PINK1 (PTEN induced putative kinase 1), a familial Parkinson's disease (PD)-related gene, is expressed in astrocytes, but little is known about its role in this cell type. Here, we found that astrocytes cultured from PINK1-knockout (KO) mice exhibit defective proliferative responses to epiderma...

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Detalhes bibliográficos
Main Authors: Choi, Insup, Kim, Jun, Jeong, Hey-Kyeong, Kim, Beomsue, Jou, Ilo, Park, Sang Myun, Chen, Linan, Kang, Un-Jung, Zhuang, Xiaoxi, Joe, Eun-hye
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657120/
https://ncbi.nlm.nih.gov/pubmed/23440919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22475
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