PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα

Opioid-induced hyperalgesia (OIH) is one of the major problems associated with prolonged use of opioids for the treatment of chronic pain. Effective treatment for OIH is lacking. In this study, we examined the efficacy and preliminary mechanism of curcumin in attenuating OIH. We employed a newly dev...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Hu, Xiaoyu, Huang, Fang, Szymusiak, Magdalena, Tian, Xuebi, Liu, Ying, Wang, Zaijie Jim
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706327/
https://ncbi.nlm.nih.gov/pubmed/26744842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146393
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