Orally Administered Nano-curcumin to Attenuate Morphine Tolerance: Comparison between Negatively Charged PLGA and Partially and Fully PEGylated Nanoparticles

We have formulated hydrophobic curcurmin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] into stable nanoparticle suspensions (nano-curcumin) to overcome its relatively low bioavailability, high rate of metabolism and rapid elimination and clearance from the body. Employing the curcum...

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Bibliografiska uppgifter
Huvudupphovsmän: Shen, Hao, Hu, Xiaoyu, Szymusiak, Magdalena, Wang, Zaijie Jim, Liu, Ying
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939066/
https://ncbi.nlm.nih.gov/pubmed/24195658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400358z
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