Cytosolic receptor MDA5 mediates Poly-ICLC preconditioning induced neuroprotection against cerebral ischemic injury

BACKGROUND AND PURPOSE: Preconditioning with poly-ICLC provides robust neuroprotection from cerebral ischemia in a mouse stroke model. However, the receptor that mediates neuroprotection is unknown. As a synthetic double stranded RNA (dsRNA) poly-ICLC may bind endosomal Toll-like receptor 3 (TLR3) o...

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Bibliografske podrobnosti
izdano v:Stroke
Main Authors: Gesuete, Raffaella, Christensen, Sara N., Bahjat, Frances R., Packard, Amy E. B., Stevens, Susan L., Liu, Mingyue, Salazar, Andres M., Stenzel-Poore, Mary P.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706072/
https://ncbi.nlm.nih.gov/pubmed/26564103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.115.010329
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