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Cytosolic receptor MDA5 mediates Poly-ICLC preconditioning induced neuroprotection against cerebral ischemic injury
BACKGROUND AND PURPOSE: Preconditioning with poly-ICLC provides robust neuroprotection from cerebral ischemia in a mouse stroke model. However, the receptor that mediates neuroprotection is unknown. As a synthetic double stranded RNA (dsRNA) poly-ICLC may bind endosomal Toll-like receptor 3 (TLR3) o...
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| Publicat a: | Stroke |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4706072/ https://ncbi.nlm.nih.gov/pubmed/26564103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.115.010329 |
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