Synthetic Bax-Anti Bcl(2) combination module actuated by super artificial hTERT promoter selectively inhibits malignant phenotypes of bladder cancer

BACKGROUND: The synthetic biology technology which enhances the specificity and efficacy of treatment is a novel try in biomedical therapy during recent years. A high frequency of somatic mutations was shown in the human telomerase reverse transcriptase (hTERT) promoter in bladder cancer, indicating...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Liu, Li, Liu, Yuchen, Zhang, Tianbiao, Wu, Hanwei, Lin, Muqi, Wang, Chaoliang, Zhan, Yonghao, Zhou, Qing, Qiao, Baoping, Sun, Xiaojuan, Zhang, Qiaoxia, Guo, Xiaoqiang, Zhao, Guoping, Zhang, Weixing, Huang, Weiren
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705585/
https://ncbi.nlm.nih.gov/pubmed/26743236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0279-6
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