Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis

Src phosphorylates Runx1 on one central and four C-terminal tyrosines. We find that activated Src synergizes with Runx1 to activate a Runx1 luciferase reporter. Mutation of the four Runx1 C-terminal tyrosines to aspartate or glutamate to mimic phosphorylation increases trans-activation of the report...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Leong, Wan Yee, Guo, Hong, Ma, Ou, Huang, Hui, Cantor, Alan B., Friedman, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705401/
https://ncbi.nlm.nih.gov/pubmed/26598521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.674234
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