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Zn(2+)-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN(2+)-INDUCED ERK MAPK ACTIVATION

Excessive release of Zn(2+) in the brain is implicated in the progression of acute brain injuries. Although several signaling cascades have been reported to be involved in Zn(2+)-induced neurotoxicity, a potential contribution of tyrosine phosphatases in this process has not been well explored. Here...

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Vydáno v:J Biol Chem
Hlavní autoři: Poddar, Ranjana, Rajagopal, Sathyanarayanan, Shuttleworth, C. William, Paul, Surojit
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705400/
https://ncbi.nlm.nih.gov/pubmed/26574547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663468
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