The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases

Glycoprotein hormones (GPHs) are the main regulators of the pituitary-thyroid and pituitary-gonadal axes. Selective interaction between GPHs and their cognate G protein-coupled receptors ensure specificity in GPH signaling. The mechanisms of how these hormones activate glycoprotein hormone receptors...

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Publicado en:J Biol Chem
Autores principales: Brüser, Antje, Schulz, Angela, Rothemund, Sven, Ricken, Albert, Calebiro, Davide, Kleinau, Gunnar, Schöneberg, Torsten
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705372/
https://ncbi.nlm.nih.gov/pubmed/26582202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701102
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