Agonist-regulated Cleavage of the Extracellular Domain of Parathyroid Hormone Receptor Type 1

The receptor for parathyroid hormone (PTHR) is a main regulator of calcium homeostasis and bone maintenance. As a member of class B of G protein-coupled receptors, it harbors a large extracellular domain, which is required for ligand binding. Here, we demonstrate that the PTHR extracellular domain i...

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Bibliographic Details
Main Authors: Klenk, Christoph, Schulz, Stefan, Calebiro, Davide, Lohse, Martin J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838289/
https://ncbi.nlm.nih.gov/pubmed/20080964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.058685
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