A Trypanosomatid Iron Transporter that Regulates Mitochondrial Function Is Required for Leishmania amazonensis Virulence

Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Mittra, Bidyottam, Laranjeira-Silva, Maria Fernanda, Perrone Bezerra de Menezes, Juliana, Jensen, Jennifer, Michailowsky, Vladimir, Andrews, Norma W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704735/
https://ncbi.nlm.nih.gov/pubmed/26741360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005340
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