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Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy
OBJECTIVE: Myotonic dystrophy type 1 (DM1) is caused by the expansion of a CTG repeat in the 3′ untranslated region of DMPK. The transcripts containing an expanded CUG repeat (CUG (exp)) result in a toxic gain‐of‐function by forming ribonuclear foci that sequester the alternative splicing factor mus...
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| Gepubliceerd in: | Ann Clin Transl Neurol |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
John Wiley and Sons Inc.
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704483/ https://ncbi.nlm.nih.gov/pubmed/26783549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.271 |
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