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Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is an RNA dominant disease in which mutant transcripts containing an expanded CUG repeat (CUG(exp)) cause muscle dysfunction by interfering with biogenesis of other mRNAs. The toxic effects of mutant RNA are mediated partly through sequestration of splicing regulator...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Osborne, Robert J., Lin, Xiaoyan, Welle, Stephen, Sobczak, Krzysztof, O'Rourke, Jason R., Swanson, Maurice S., Thornton, Charles A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664149/
https://ncbi.nlm.nih.gov/pubmed/19223393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp058
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