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Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is an RNA dominant disease in which mutant transcripts containing an expanded CUG repeat (CUG(exp)) cause muscle dysfunction by interfering with biogenesis of other mRNAs. The toxic effects of mutant RNA are mediated partly through sequestration of splicing regulator...

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Bibliografische gegevens
Hoofdauteurs: Osborne, Robert J., Lin, Xiaoyan, Welle, Stephen, Sobczak, Krzysztof, O'Rourke, Jason R., Swanson, Maurice S., Thornton, Charles A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664149/
https://ncbi.nlm.nih.gov/pubmed/19223393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp058
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