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Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy
Myotonic dystrophy type 1 (DM1) is an RNA dominant disease in which mutant transcripts containing an expanded CUG repeat (CUG(exp)) cause muscle dysfunction by interfering with biogenesis of other mRNAs. The toxic effects of mutant RNA are mediated partly through sequestration of splicing regulator...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664149/ https://ncbi.nlm.nih.gov/pubmed/19223393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp058 |
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