Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis

Rifabutin, used to treat HIV-infected tuberculosis, shows highly variable drug exposure, complicating dosing. Effects of SLCO1B1 polymorphisms on rifabutin pharmacokinetics were investigated in 35 African HIV-infected tuberculosis patients after multiple doses. Nonlinear mixed-effects modeling found...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Hennig, Stefanie, Naiker, Suhashni, Reddy, Tarylee, Egan, Deirdre, Kellerman, Tracy, Wiesner, Lubbe, Owen, Andrew, McIlleron, Helen, Pym, Alexander
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2015
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704238/
https://ncbi.nlm.nih.gov/pubmed/26482301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01195-15
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