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Efficacy of Extended-Interval Dosing of Micafungin Evaluated Using a Pharmacokinetic/Pharmacodynamic Study with Humanized Doses in Mice

The pharmacokinetic/pharmacodynamic (PK/PD) characteristics of the echinocandins favor infrequent administration of large doses. The in vivo investigation reported here tested the utility of a range of humanized dose levels of micafungin using a variety of prolonged dosing intervals for the preventi...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Lepak, A., Marchillo, K., VanHecker, J., Azie, N., Andes, D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704180/
https://ncbi.nlm.nih.gov/pubmed/26552968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02124-15
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