Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors

Concomitant with the release of human immunodeficiency virus type 1 (HIV-1) particles from the infected cell, the viral protease cleaves the Gag polyprotein precursor at a number of sites to trigger virus maturation. We previously reported that a betulinic acid-derived compound, bevirimat (BVM), blo...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Urano, Emiko, Ablan, Sherimay D., Mandt, Rebecca, Pauly, Gary T., Sigano, Dina M., Schneider, Joel P., Martin, David E., Nitz, Theodore J., Wild, Carl T., Freed, Eric O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704169/
https://ncbi.nlm.nih.gov/pubmed/26482309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02121-15
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