Cefotaxime and Amoxicillin-Clavulanate Synergism against Extended-Spectrum-β-Lactamase-Producing Escherichia coli in a Murine Model of Urinary Tract Infection

We investigated the efficacies of cefotaxime (CTX) and amoxicillin (AMX)-clavulanate (CLA) (AMC) against extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli in vitro and in a murine model of urinary tract infection (UTI). MICs, the checkerboard dilution method, and time-kill curves were...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Rossi, B., Soubirou, J. F., Chau, F., Massias, L., Dion, S., Lepeule, R., Fantin, B., Lefort, A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704162/
https://ncbi.nlm.nih.gov/pubmed/26525800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02018-15
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