Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase

The heme-containing enzymes indoleamine 2,3-dioxygenase-1 (IDO-1) and IDO-2 catalyze the conversion of the essential amino acid tryptophan into kynurenine. Metabolites of the kynurenine pathway and IDO itself are involved in immunity and the pathology of several diseases, having either immunoregulat...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Jortzik, Esther, Zocher, Kathleen, Isernhagen, Antje, Mailu, Boniface M., Rahlfs, Stefan, Viola, Giampietro, Wittlin, Sergio, Hunt, Nicholas H., Ihmels, Heiko, Becker, Katja
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704160/
https://ncbi.nlm.nih.gov/pubmed/26459907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01066-15
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