Antimalarial drug chloroquine counteracts activation of indoleamine (2,3)-dioxygenase activity in human PBMC

Antimalarial chloroquine is also used for the treatment of immune-mediated diseases. The interference of chloroquine with interferon-γ-induced tryptophan breakdown and neopterin production has been investigated in human peripheral blood mononuclear cells (PBMC) in vitro. Micromolar concentrations (2...

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Main Authors: Gostner, Johanna M., Schröcksnadel, Sebastian, Becker, Kathrin, Jenny, Marcel, Schennach, Harald, Überall, Florian, Fuchs, Dietmar
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642164/
https://ncbi.nlm.nih.gov/pubmed/23650606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2012.08.004
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