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Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch

RepoMan is a scaffold for signalling by mitotic phosphatases at the chromosomes. During (pro)metaphase, RepoMan-associated protein phosphatases PP1 and PP2A-B56 regulate the chromosome targeting of Aurora-B kinase and RepoMan, respectively. Here we show that this task division is critically dependen...

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Publicat a:Nat Commun
Autors principals: Qian, Junbin, Beullens, Monique, Huang, Jin, De Munter, Sofie, Lesage, Bart, Bollen, Mathieu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703885/
https://ncbi.nlm.nih.gov/pubmed/26674376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10215
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