Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**

THE FIRST CELL-PENETRATING PEPTIDE: that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach...

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Main Authors: Chatterjee, Jayanta, Beullens, Monique, Sukackaite, Rasa, Qian, Junbin, Lesage, Bart, Hart, Darren J, Bollen, Mathieu, Köhn, Maja
Format: Artigo
Jezik:Inglês
Izdano: WILEY-VCH Verlag 2012
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531619/
https://ncbi.nlm.nih.gov/pubmed/22962028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201204308
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