Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression

In primates, puberty is unleashed by increased GnRH release from the hypothalamus following an interval of juvenile quiescence. GWAS implicates Zinc finger (ZNF) genes in timing human puberty. Here we show that hypothalamic expression of several ZNFs decreased in agonadal male monkeys in association...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Lomniczi, Alejandro, Wright, Hollis, Castellano, Juan Manuel, Matagne, Valerie, Toro, Carlos A., Ramaswamy, Suresh, Plant, Tony M., Ojeda, Sergio R.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703871/
https://ncbi.nlm.nih.gov/pubmed/26671628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10195
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