Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

The mechanism of action of artemisinin and its derivatives, the most potent of the anti-malarial drugs, is not completely understood. Here we present an unbiased chemical proteomics analysis to directly explore this mechanism in Plasmodium falciparum. We use an alkyne-tagged artemisinin analogue cou...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Jigang, Zhang, Chong-Jing, Chia, Wan Ni, Loh, Cheryl C. Y., Li, Zhengjun, Lee, Yew Mun, He, Yingke, Yuan, Li-Xia, Lim, Teck Kwang, Liu, Min, Liew, Chin Xia, Lee, Yan Quan, Zhang, Jianbin, Lu, Nianci, Lim, Chwee Teck, Hua, Zi-Chun, Liu, Bin, Shen, Han-Ming, Tan, Kevin S. W., Lin, Qingsong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703832/
https://ncbi.nlm.nih.gov/pubmed/26694030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10111
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