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Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives

Targeting mitotic regulators as a strategy to fight cancer implies the development of drugs against key proteins, such as Aurora-A and -B. Current drugs, which target mitosis through a general mechanism of action (stabilization/destabilization of microtubules), have several side effects (neutropenia...

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Bibliografische gegevens
Gepubliceerd in:Front Oncol
Hoofdauteurs: Marugán, Carlos, Torres, Raquel, Lallena, María José
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703775/
https://ncbi.nlm.nih.gov/pubmed/26779442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00299
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