Interactions between ibrutinib and anti-CD20 antibodies; competing effects on the outcome of combination therapy

PURPOSE: Clinical trials of ibrutinib combined with anti-CD20 monoclonal antibodies (mAbs) for chronic lymphocytic leukemia (CLL) report encouraging results. Paradoxically, in pre-clinical studies in vitro ibrutinib was reported to decrease CD20 expression and inhibits cellular effector mechanisms....

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Skarzynski, Martin, Niemann, Carsten U, Lee, Yuh Shan, Martyr, Sabrina, Maric, Irina, Salem, Dalia, Stetler-Stevenson, Maryalice, Marti, Gerald E, Calvo, Katherine R, Yuan, Constance, Valdez, Janet, Soto, Susan, Farooqui, Mohammed Z.H., Herman, Sarah E.M., Wiestner, Adrian
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703510/
https://ncbi.nlm.nih.gov/pubmed/26283682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1304
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