Disruption of in vivo chronic lymphocytic leukemia tumor-microenvironment interactions by ibrutinib – findings from an investigator initiated phase 2 study

PURPOSE: Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental interactions for proliferation and survival that are at least partially mediated through B cell receptor (BCR) signaling. Ibrutinib, a Bruton’s tyrosine kinase inhibitor, disrupts BCR signaling and leads to the egress of...

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Publicado no:Clin Cancer Res
Main Authors: Niemann, Carsten U., Herman, Sarah E. M., Maric, Irina, Gomez-Rodriguez, Julio, Biancotto, Angelique, Chang, Betty Y., Martyr, Sabrina, Stetler-Stevenson, Maryalice, Yuan, Constance, Calvo, Katherine R., Braylan, Raul C., Valdez, Janet, Lee, Yuh Shan, Wong, Deanna H., Jones, Jade, Sun, Clare C. L., Marti, Gerald E., Farooqui, Mohammed Z., Wiestner, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818677/
https://ncbi.nlm.nih.gov/pubmed/26660519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1965
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