Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4). Over-expression of Plk4 from this transgene advances the onset of t...

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Vydáno v:Open Biol
Hlavní autoři: Coelho, Paula A., Bury, Leah, Shahbazi, Marta N., Liakath-Ali, Kifayathullah, Tate, Peri H., Wormald, Sam, Hindley, Christopher J., Huch, Meritxell, Archer, Joy, Skarnes, William C., Zernicka-Goetz, Magdalena, Glover, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2015
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703062/
https://ncbi.nlm.nih.gov/pubmed/26701933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.150209
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