Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

Inflammation is inextricably associated with primary tumor progression. However, the contribution of inflammation to tumor outgrowth in metastatic organs has remained underexplored. Here, we show that extrinsic inflammation in the lungs leads to the recruitment of bone marrow-derived neutrophils, wh...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: El Rayes, Tina, Catena, Raúl, Lee, Sharrell, Stawowczyk, Marcin, Joshi, Natasha, Fischbach, Claudia, Powell, Charles A., Dannenberg, Andrew J., Altorki, Nasser K., Gao, Dingcheng, Mittal, Vivek
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703007/
https://ncbi.nlm.nih.gov/pubmed/26668367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507294112
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