Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo

Adeno-associated virus 2 (AAV2) and adenovirus 5 (Ad5) are promising gene therapy vectors. Both display liver tropism and are currently thought to enter hepatocytes in vivo through cell surface heparan sulfate proteoglycans (HSPGs). To test directly this hypothesis, we created mice that lack Ext1, a...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zaiss, Anne K., Foley, Erin M., Lawrence, Roger, Schneider, Lina S., Hoveida, Hamidreza, Secrest, Patrick, Catapang, Arthur B., Yamaguchi, Yu, Alemany, Ramon, Shayakhmetov, Dmitry M., Esko, Jeffrey D., Herschman, Harvey R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702579/
https://ncbi.nlm.nih.gov/pubmed/26491162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01939-15
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