Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest

Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Ren, Yizhong, Li, Chufang, Feng, Liqiang, Pan, Weiqi, Li, Liang, Wang, Qian, Li, Jiashun, Li, Na, Han, Ling, Zheng, Xuehua, Niu, Xuefeng, Sun, Caijun, Chen, Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Cellular Response to Infection
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702553/
https://ncbi.nlm.nih.gov/pubmed/26468520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00576-15
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