Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest

Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ren, Yizhong, Li, Chufang, Feng, Liqiang, Pan, Weiqi, Li, Liang, Wang, Qian, Li, Jiashun, Li, Na, Han, Ling, Zheng, Xuehua, Niu, Xuefeng, Sun, Caijun, Chen, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702553/
https://ncbi.nlm.nih.gov/pubmed/26468520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00576-15
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