Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System

Interferon (IFN)-regulatory factor 5 (IRF-5) is a transcription factor that induces inflammatory responses after engagement and signaling by pattern recognition receptors. To define the role of IRF-5 during bunyavirus infection, we evaluated Oropouche virus (OROV) and La Crosse virus (LACV) pathogen...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Proenca-Modena, Jose Luiz, Hyde, Jennifer L., Sesti-Costa, Renata, Lucas, Tiffany, Pinto, Amelia K., Richner, Justin M., Gorman, Matthew J., Lazear, Helen M., Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702527/
https://ncbi.nlm.nih.gov/pubmed/26468541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02276-15
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