Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer

Targeting dysregulated metabolic pathways is a promising therapeutic strategy for eradicating cancer. Understanding how frequently altered oncogenes regulate metabolic enzyme targets would be useful in identifying both broad-spectrum and targeted metabolic therapies for cancer. Here, we used activit...

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Bibliografische gegevens
Gepubliceerd in:ACS Chem Biol
Hoofdauteurs: Kohnz, Rebecca A., Mulvihill, Melinda M., Chang, Jae Won, Hsu, Ku-Lung, Sorrentino, Antonio, Cravatt, Benjamin F., Bandyopadhyay, Sourav, Goga, Andrei, Nomura, Daniel K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702252/
https://ncbi.nlm.nih.gov/pubmed/25945974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00053
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