E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis

E2F transcription factors are known regulators of the cell cycle, proliferation, apoptosis, and differentiation. Here, we reveal that E2F1 plays an essential role in liver physiopathology through the regulation of glycolysis and lipogenesis. We demonstrate that E2F1 deficiency leads to a decrease in...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Denechaud, Pierre-Damien, Lopez-Mejia, Isabel C., Giralt, Albert, Lai, Qiuwen, Blanchet, Emilie, Delacuisine, Brigitte, Nicolay, Brandon N., Dyson, Nicholas J., Bonner, Caroline, Pattou, François, Annicotte, Jean-Sébastien, Fajas, Lluis
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701565/
https://ncbi.nlm.nih.gov/pubmed/26619117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81542
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