E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis

E2F transcription factors are known regulators of the cell cycle, proliferation, apoptosis, and differentiation. Here, we reveal that E2F1 plays an essential role in liver physiopathology through the regulation of glycolysis and lipogenesis. We demonstrate that E2F1 deficiency leads to a decrease in...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Denechaud, Pierre-Damien, Lopez-Mejia, Isabel C., Giralt, Albert, Lai, Qiuwen, Blanchet, Emilie, Delacuisine, Brigitte, Nicolay, Brandon N., Dyson, Nicholas J., Bonner, Caroline, Pattou, François, Annicotte, Jean-Sébastien, Fajas, Lluis
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701565/
https://ncbi.nlm.nih.gov/pubmed/26619117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81542
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