Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

BACKGROUND. Recurrence and/or metastasis occurs in more than half of patients with head and neck squamous cell carcinoma (HNSCC), and these events pose the greatest threats to long-term survival. We set out to identify genetic alterations that underlie recurrent/metastatic HNSCC. METHODS. Whole-exom...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Hedberg, Matthew L., Goh, Gerald, Chiosea, Simion I., Bauman, Julie E., Freilino, Maria L., Zeng, Yan, Wang, Lin, Diergaarde, Brenda B., Gooding, William E., Lui, Vivian W.Y., Herbst, Roy S., Lifton, Richard P., Grandis, Jennifer R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701554/
https://ncbi.nlm.nih.gov/pubmed/26619122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82066
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