Phosphorylating Titin’s Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force

Titin is a large filamentous protein that is responsible for the passive force of the cardiac sarcomere. Titin’s force is generated by its I-band region, which includes the cardiac-specific N2B element. The N2B element consists of three immunoglobulin domains, two small unique sequence insertions, a...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Perkin, John, Slater, Rebecca, Del Favero, Giorgia, Lanzicher, Thomas, Hidalgo, Carlos, Anderson, Brian, Smith, John E., Sbaizero, Orfeo, Labeit, Siegfried, Granzier, Henk
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2015
Fag:
Molecular Machines, Motors, and Nanoscale Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701010/
https://ncbi.nlm.nih.gov/pubmed/26682816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.11.002
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