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Chronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats

The nitric oxide (NO)/soluble guanylate cyclase (sGC)/cyclic guanosine monophasphate (cGMP)-signalling pathway is impaired under oxidative stress conditions due to oxidation and subsequent loss of the prosthetic sGC heme group as observed in particular in chronic renal failure. Thus, the pool of hem...

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Vydáno v:PLoS One
Hlavní autoři: Hoffmann, Linda S., Kretschmer, Axel, Lawrenz, Bettina, Hocher, Berthold, Stasch, Johannes-Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700984/
https://ncbi.nlm.nih.gov/pubmed/26717150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145048
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