NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy

1. Chronic renal disease is associated with oxidative stress, reduced nitric oxide (NO) availability and soluble guanylate cyclase (sGC) dysfunction. Recently, we discovered BAY 58-2667, a compound activating heme-deficient or oxidized sGC in a NO-independent manner. 2. We assessed potential of BAY...

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Autori principali: Kalk, Philipp, Godes, Michael, Relle, Katharina, Rothkegel, Christiane, Hucke, Andreas, Stasch, Johannes-Peter, Hocher, Berthold
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2006
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617071/
https://ncbi.nlm.nih.gov/pubmed/16770325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706792
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