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Single point mutation in adeno-associated viral vectors -DJ capsid leads to improvement for gene delivery in vivo
BACKGROUND: Rational design of AAV capsids is a simple method for enhancing AAV transduction efficiency. AAV-DJ is a highly recombinogenic hybrid vector created from DNA shuffling of eight AAV serotypes, which mediates efficient gene expression both in vitro and in vivo. AAV2 and AAV8 are the closes...
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| Publicado no: | BMC Biotechnol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4700607/ https://ncbi.nlm.nih.gov/pubmed/26729248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0230-0 |
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