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Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome

BACKGROUND: Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 signaling was depressed and overall translation was reduced in RBS cells and zebrafish models for RBS. Treatment of RBS cells and zebraf...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:BMC Genomics
Päätekijät: Xu, Baoshan, Gogol, Madelaine, Gaudenz, Karin, Gerton, Jennifer L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700579/
https://ncbi.nlm.nih.gov/pubmed/26729373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-2354-y
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