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Asymmetric Synthesis of Highly Functionalized Tetrahydropyrans via a One-Pot Organocatalytic Michael/Henry/Ketalization Sequence

A diastereo- and enantioselective Michael/Henry/ketalization sequence to functionalized tetrahydropyrans is described. The multicomponent cascade reaction uses acetylacetone or β-keto esters, β-nitrostyrenes, and alkynyl aldehydes as substrates affording tetrahydropyrans with five contiguous stereoc...

詳細記述

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書誌詳細
出版年:Org Lett
主要な著者: Hahn, Robert, Raabe, Gerhard, Enders, Dieter
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700516/
https://ncbi.nlm.nih.gov/pubmed/24971998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol501236a
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