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Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming

Farnesoid X receptor (FXR) plays a pivotal role in the regulation of various metabolic pathways as well as liver regeneration. However, the casual link between cell proliferative effects during liver regeneration and metabolic regulation of FXR was elusive. In this study, we found that FXR activatio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Xie, Yang, Wang, Hong, Cheng, Xuefang, Wu, Yuzheng, Cao, Lijuan, Wu, Mengqiu, Xie, Wen, Wang, Guangji, Hao, Haiping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700422/
https://ncbi.nlm.nih.gov/pubmed/26728993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18751
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