A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

Acute myeloid leukemia (AML) is a heterogeneous and fatal disease with an urgent need for improved therapeutic regimens given that most patients die from relapsed disease. Irrespective of mutation status, the development of aggressive leukemias is enabled by increasing dependence on signaling networ...

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Pubblicato in:Cell Rep
Autori principali: Zong, Hongliang, Gozman, Alexander, Caldas-Lopes, Eloisi, Taldone, Tony, Sturgill, Eric, Brennan, Sarah, Ochiana, Stefan O., Gomes-DaGama, Erica M., Sen, Siddhartha, Rodina, Anna, Koren, John, Becker, Michael W., Rudin, Charles M., Melnick, Ari, Levine, Ross L., Roboz, Gail J., Nimer, Stephen D., Chiosis, Gabriela, Guzman, Monica L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699804/
https://ncbi.nlm.nih.gov/pubmed/26628369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.073
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