Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia

Hypoxic tumor cells are known to be more resistant to conventional chemotherapy and radiation than normoxic cells. However, the effects of 2-methoxyestradiol (2-ME), an anti-angiogenic, antiproliferative and pro-apoptotic drug, on hypoxic lung cancer cells are unknown. The aim of the present study w...

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Publicado no:Oncol Rep
Main Authors: AQUINO-GÁLVEZ, ARNOLDO, GONZÁLEZ-ÁVILA, GEORGINA, DELGADO-TELLO, JAVIER, CASTILLEJOS-LÓPEZ, MANUEL, MENDOZA-MILLA, CRISELDA, ZÚÑIGA, JOAQUÍN, CHECA, MARCO, MALDONADO-MARTÍNEZ, HÉCTOR AQUILES, TRINIDAD-LÓPEZ, AXEL, CISNEROS, JOSÉ, TORRES-ESPÍNDOLA, LUZ MARÍA, HERNÁNDEZ-JIMÉNEZ, CLAUDIA, SOMMER, BETTINA, CABELLO-GUTIÉRREZ, CARLOS, GUTIÉRREZ-GONZÁLEZ, LUIS H.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699616/
https://ncbi.nlm.nih.gov/pubmed/26548300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2015.4399
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