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Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

In this Communication, we describe an enzyme-responsive, paclitaxel-loaded nanoparticle and assess its safety and efficacy in vivo in a human fibrosarcoma murine xenograft. The material was generated via graft-through block copolymerization of norbornene monomers with hydrophilic targeting peptides...

Полное описание

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Библиографические подробности
Опубликовано в: :Adv Mater
Главные авторы: Callmann, Cassandra E., Barback, Christopher V., Thompson, Matthew P., Hall, David J., Mattrey, Robert F., Gianneschi, Nathan C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699560/
https://ncbi.nlm.nih.gov/pubmed/26178920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201501803
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