Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction

Herein, we describe a method for targeting to and retaining intravenously (IV) injected nanoparticles at the site of acute myocardial infarction (MI) in a rat model. Enzyme-responsive peptide-polymer amphiphiles (PPAs) were prepared and assembled as spherical micellar nanoparticles. The resulting na...

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Pubblicato in:Adv Mater
Autori principali: Nguyen, Mary M., Carlini, Andrea S., Chien, Miao-Ping, Sonnenberg, Sonya, Luo, Colin, Braden, Rebecca L., Osborn, Kent G., Li, Yiwen, Gianneschi, Nathan C., Christman, Karen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699559/
https://ncbi.nlm.nih.gov/pubmed/26305446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201502003
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