Vorinostat with Sustained Exposure and High Solubility in Poly(ethylene glycol)-b-poly(DL-lactic acid) Micelle Nanocarriers: Characterization and Effects on Pharmacokinetics in Rat Serum and Urine

The histone deacetylase inhibitor suberoylanilide hydroxamic acid, known as vorinostat, is a promising anti-cancer drug with a unique mode of action; however, it is plagued by low water solubility, low permeability, and suboptimal pharmacokinetics. In this study, poly(ethylene glycol)-b-poly(DL-lact...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Mohamed, Elham A., Zhao, Yunqi, Meshali, Mahasen M., Remsberg, Connie M., Borg, Thanaa M., Foda, Abdel Monem M., Takemoto, Jody K., Sayre, Casey, Martinez, Stephanie, Davies, Neal M., Forrest, M. Laird
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699555/
https://ncbi.nlm.nih.gov/pubmed/22806441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23265
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