Vorinostat with Sustained Exposure and High Solubility in Poly(ethylene glycol)-b-poly(DL-lactic acid) Micelle Nanocarriers: Characterization and Effects on Pharmacokinetics in Rat Serum and Urine

The histone deacetylase inhibitor suberoylanilide hydroxamic acid, known as vorinostat, is a promising anti-cancer drug with a unique mode of action; however, it is plagued by low water solubility, low permeability, and suboptimal pharmacokinetics. In this study, poly(ethylene glycol)-b-poly(DL-lact...

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Veröffentlicht in:J Pharm Sci
Hauptverfasser: Mohamed, Elham A., Zhao, Yunqi, Meshali, Mahasen M., Remsberg, Connie M., Borg, Thanaa M., Foda, Abdel Monem M., Takemoto, Jody K., Sayre, Casey, Martinez, Stephanie, Davies, Neal M., Forrest, M. Laird
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699555/
https://ncbi.nlm.nih.gov/pubmed/22806441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23265
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