Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation

BACKGROUND: CpG methylation variation is involved in human trait formation and disease susceptibility. Analyses within populations have been biased towards CpG-dense regions through the application of targeted arrays. We generate whole-genome bisulfite sequencing data for approximately 30 adipose an...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Busche, Stephan, Shao, Xiaojian, Caron, Maxime, Kwan, Tony, Allum, Fiona, Cheung, Warren A., Ge, Bing, Westfall, Susan, Simon, Marie-Michelle, Barrett, Amy, Bell, Jordana T., McCarthy, Mark I., Deloukas, Panos, Blanchette, Mathieu, Bourque, Guillaume, Spector, Timothy D., Lathrop, Mark, Pastinen, Tomi, Grundberg, Elin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699357/
https://ncbi.nlm.nih.gov/pubmed/26699896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0856-1
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